Long-term potentiation disrupts auditory gating in the rat hippocampus.

@article{Miller1995LongtermPD,
  title={Long-term potentiation disrupts auditory gating in the rat hippocampus.},
  author={Chris L. Miller and Paula C Bickford and Amir Wiser and Gregory M. Rose},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 8},
  pages={5820-30}
}
The consequence of long-term potentiation (LTP) of hippocampal commissural inputs was investigated in an auditory gating paradigm. Auditory evoked potentials (AEPs) were recorded in the CA3b region of the hippocampus of rats anesthesitized with chloral hydrate. Two tones were delivered 0.5 sec apart; in this paradigm, the second AEP is diminished compared to the first. Electrical stimulation was applied to hippocampal commissural fibers to generate field potentials and population spikes which… CONTINUE READING

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