Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo

  title={Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo},
  author={Ruth Drdla and J{\"u}rgen Sandk{\"u}hler},
  journal={Molecular Pain},
  pages={18 - 18}
Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-lasting hyperalgesia. Long-term potentiation (LTP) at synapses of primary afferent C-fibres is considered to underlie some forms of hyperalgesia. In previous studies, high- but not low-frequency conditioning stimulation of C-fibres has, however, been used to induce LTP in pain pathways. Recently we could show that also conditioning low-frequency stimulation (LFS) at C-fibre intensity induces LTP in… CONTINUE READING


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