Long-term potentiation and the ageing brain.

  • Carol A. Barnes
  • Published 2003 in
    Philosophical transactions of the Royal Society…


Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

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@article{Barnes2003LongtermPA, title={Long-term potentiation and the ageing brain.}, author={Carol A. Barnes}, journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, year={2003}, volume={358 1432}, pages={765-72} }