Long-term potentiation and depression induced by a stochastic conditioning of a model synapse.

@article{Migliore1999LongtermPA,
  title={Long-term potentiation and depression induced by a stochastic conditioning of a model synapse.},
  author={Michele Migliore and Petr L{\'a}nsk{\'y}},
  journal={Biophysical journal},
  year={1999},
  volume={77 3},
  pages={
          1234-43
        }
}
Protracted presynaptic activity can induce long-term potentiation (LTP) or long-term depression (LTD) of the synaptic strength. However, virtually all the experiments testing how LTP and LTD depend on the conditioning input are carried out with trains of stimuli at constant frequencies, whereas neurons in vivo most likely experience a stochastic variation of interstimulus intervals. We used a computational model of synaptic transmission to test if and to what extent the stochastic fluctuations… CONTINUE READING
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