Long-term potentiation--a decade of progress?

  title={Long-term potentiation--a decade of progress?},
  author={Robert C. Malenka and Roger A Nicoll},
  volume={285 5435},
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory. 

The long-term potential of LTP

Long-term potentiation remains a prime candidate for mediating circuit modifications during development and experience-dependent plasticity and will certainly continue to entice neuroscientists throughout the twenty-first century.

Transcriptional regulation of long-term potentiation

Identification of all the proteins and non-coding RNA transcripts expressed during LTP may provide greater insight into the molecular mechanisms involved in learning and memory formation.

Neurobiology: Self-regulating synapses

A new way of altering synaptic properties in response to activity involves changes in the composition and function of AMPA-type receptors for the neurotransmitter glutamate.

Synaptic Plasticity in an Altered State


While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.

Long-term potentiation : One Kind or Many ? 1

This chapter suggests that this 43year history of research on long-term potentiation research supports the idea that the structure of scientific practice surrounding LTP research has remained an obstacle to the discovery of natural kinds.

Genetic Approaches to the Study of Synaptic Plasticity and Memory Storage

How strains of mice with alterations in the cyclic adenosine monophosphate/protein kinase A/cyclic adenoine monophile-response element-binding protein signaling pathway have advanced the understanding of the biological basis of learning and memory is reviewed.

Synaptic plasticity: A molecular memory switch

Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

The current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.



A synaptic model of memory: long-term potentiation in the hippocampus

The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.

Locally distributed synaptic potentiation in the hippocampus.

The data presented here indicate that long-term potentiation can be communicated between synapses on neighboring neurons by means of a diffusible messenger, which provides a mechanism for the cooperative strengthening of proximal synapses and may underlie a variety of plastic processes in the nervous system.

Synaptic plasticity: hippocampal LTP

Mechanisms underlying long-term potentiation of synaptic transmission.

A curious property of excitatory synapses in the hippocampus and some other neural tissues is that when they are heavily used, they undergo a long­ lasting increase in their efficacy. Brief

Changes in reliability of synaptic function as a mechanism for plasticity

It is found that LTP increases synaptic reliability, and LTD decreases it, both without a change in the size of those postsynaptic currents that do occur, thus LTD is a functional inverse of LTP.

Long-Term Potentiation in the CA1 Hippocampus

Two recent papers have shed light using techniques in which only one or a few axons are stimulated on the role of synaptic transmission during long-term potentiation in CAl hippocampus, a widely studied cellular model of learning and memory.

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1. The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits