Long-term potentiation--a decade of progress?

@article{Malenka1999LongtermPD,
  title={Long-term potentiation--a decade of progress?},
  author={Robert C. Malenka and Roger A Nicoll},
  journal={Science},
  year={1999},
  volume={285 5435},
  pages={
          1870-4
        }
}
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory. 

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This chapter suggests that this 43year history of research on long-term potentiation research supports the idea that the structure of scientific practice surrounding LTP research has remained an obstacle to the discovery of natural kinds.

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