Long-term potentiation: evidence against an increase in transmitter release probability in the CA1 region of the hippocampus.

@article{Manabe1994LongtermPE,
  title={Long-term potentiation: evidence against an increase in transmitter release probability in the CA1 region of the hippocampus.},
  author={Toshiya Manabe and Roger A Nicoll},
  journal={Science},
  year={1994},
  volume={265 5180},
  pages={
          1888-92
        }
}
It is widely accepted that N-methyl-D-aspartate (NMDA)-receptor-dependent long-term potentiation (LTP) in the CA1 region of the hippocampus is triggered postsynaptically, but there is considerable debate as to the site at which the increase in synaptic strength is expressed. The irreversible open-channel blocking action of the NMDA receptor antagonist MK-801 has been used to test whether the probability of transmitter release (Pr) is increased during LTP. Although the rate of decline of the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 60 CITATIONS, ESTIMATED 57% COVERAGE

A Brief History of Long-Term Potentiation

  • Neuron
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS

FILTER CITATIONS BY YEAR

1995
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations