Long-term post-operative cognitive decline in the elderly: the effects of anesthesia type, apolipoprotein E genotype, and clinical antecedents.

@article{Ancelin2010LongtermPC,
  title={Long-term post-operative cognitive decline in the elderly: the effects of anesthesia type, apolipoprotein E genotype, and clinical antecedents.},
  author={M-L. Ancelin and Guilhem de Roquefeuil and Jacqueline Scali and François Bonnel and J Adam and J C Cheminal and Jean-Paul Cristol and Aur{\'e}lien G Dupuy and Isabelle Carri{\`e}re and Karen Ritchie},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={22 Suppl 3},
  pages={
          105-13
        }
}
Cognitive dysfunction in the elderly commonly observed following anesthesia has been attributed to age-related neuronal changes exacerbated by pharmacotoxic effects. However, the extent to which these changes may persist following recovery from surgery is still largely unknown. This study investigates the long-term effects of anesthesia on cognitive functioning after orthopedic surgery in 270 elderly patients over the age of 65 who completed a computerized cognitive battery before and 8 days, 4… CONTINUE READING

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