Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneity.

@article{Fernndez2004LongtermPO,
  title={Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneity.},
  author={Javier Fern{\'a}ndez and Deborah Taylor and Duncan R. Morhardt and Kathleen B Mihalik and Montserrat Puig and Charles M. Rice and Stephen M. Feinstone and Marian E Major},
  journal={Journal of virology},
  year={2004},
  volume={78 18},
  pages={
          9782-9
        }
}
Two chimpanzees, 1535 and 1536, became persistently infected following inoculation with RNA transcripts from cDNA clones of hepatitis C virus (HCV). Analysis of the HCV genomes from both animals showed an accumulation of amino acid substitutions over time. The appearance of substitutions in the envelope genes was associated with increased antienvelope antibody titers. However, extensive mutations were not incorporated into hypervariable region 1 (HVR1). A comparison of the nonsynonymous… CONTINUE READING

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