Long-term persistence of hormonal adaptations to weight loss.

@article{Sumithran2011LongtermPO,
  title={Long-term persistence of hormonal adaptations to weight loss.},
  author={Priya Sumithran and Luke A. Prendergast and Elizabeth Delbridge and Katrina Purcell and Arthur Shulkes and Adamandia D. Kriketos and Joseph Proietto},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 17},
  pages={
          1597-604
        }
}
BACKGROUND After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur. [] Key MethodMETHODS We enrolled 50 overweight or obese patients without diabetes in a 10-week weight-loss program for which a very-low-energy diet was prescribed.

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References

SHOWING 1-10 OF 41 REFERENCES

Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations.

Investigation of circulating metabolites and hunger-satiety responses before and after weight loss found rapid weight loss results in a reduction in postprandial CCK and FFA concentrations.

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.

Declines in energy expenditure favoring the regain of lost weight persist well beyond the period of dynamic weight loss.

Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels

Reduced PYY levels after weight loss by an energy- restricted low-fat or low-carbohydrate diet likely represents a compensatory response to maintain energy homeostasis and contributes to difficulty in weight loss during energy-restricted diets.

Serum leptin and weight reduction in female obesity.

The rapid and persistent decrease in serum leptin to lower levels than expected from matched controls may explain the pertinent difficulties of obese subjects to cope with weight reduction.

Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.

The increase in the plasma ghrelin level with diet-induced weight loss is consistent with the hypothesis that gh Relin has a role in the long-term regulation of body weight.

Effects of weight change on plasma leptin concentrations and energy expenditure.

Though plasma leptin is significantly reduced during dynamic weight loss compared with static weight maintenance at the same body weight, the lack of correlation between changes in plasma leptin and changes in energy expenditure between weight plateaus suggests that leptin is not the primary signal that mediates the changes of energy expenditure that accompany the maintenance of an altered body weight in humans.

Changes in energy expenditure resulting from altered body weight.

Maintenance of a reduced or elevated body weight is associated with compensatory changes in energy expenditure, which oppose the maintenance of a body weight that is different from the usual weight, which may account for the poor long-term efficacy of treatments for obesity.

Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats.

An enhanced metabolic efficiency and an elevated appetite both contribute to a large potential energy imbalance that, when the forcible control of energy intake is relieved, becomes actualized and results in an exceptionally high rate of weight regain.

Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women.

Findings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long-term regulation of food intake warrants further study.

Pancreatic polypeptide in obese children before and after weight loss

PP concentrations are decreased in obese children and independent of age, gender, pubertal stage, leptin and insulin, therefore, low PP concentrations reflect the overweight status, rather than cause it.