Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation.

@article{McGrath2010LongtermPO,
  title={Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation.},
  author={Samuel D McGrath and John Vito Antonucci and Neal S. Goldstein and Michelle F Wallace and Chris Mitchell and Inga Siiner Grills and Shruti Jolly and Larry Llyn Kestin and Frank A. Vicini},
  journal={American journal of clinical oncology},
  year={2010},
  volume={33 1},
  pages={17-22}
}
BACKGROUND The clonality of ipsilateral breast tumor recurrences (IBTR) after breast-conserving therapy (BCT) was established using a polymerase chain reaction-based allelic imbalance assay of microsatellite loci to compare tumor suppressor gene alteration patterns. METHODS The clonality of IBTRs relative to the initial invasive carcinomas were analyzed using a polymerase chain reaction-based allelic imbalance assay in 57 patients treated with BCT, including both whole breast irradiation and… CONTINUE READING

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