Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants.

@article{EstradaCamarena2011LongtermOM,
  title={Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants.},
  author={Erika Estrada-Camarena and Carolina L{\'o}pez-Rubalcava and Azucena Hern{\'a}ndez-Arag{\'o}n and Silvia Mej{\'i}a-Mauries and O. Picazo},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 10},
  pages={
          1365-77
        }
}
Controversial results related to effectiveness of estrogen replacement therapy (ERT) to alleviate depression are frequently reported. The discrepancies could be related to (a) time when ERT is initiated after the beginning of menopause and/or (b) type of estrogen used. Furthermore, estrogens modulate the antidepressant effect of different compounds; therefore, the effectiveness of antidepressant drugs could also depend on the menopausal status. The aim of the present study was to analyze… CONTINUE READING
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