Long-term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis*

@article{Louis2012LongtermOO,
  title={Long-term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis*},
  author={Guillaume Louis and Bruno M{\'e}garbane and Sylvain Lavou{\'e} and Vincent Lassalle and Laurent Argaud and Jean François Poussel and Hugues Georges and Pierre Edouard Bollaert},
  journal={Critical Care Medicine},
  year={2012},
  volume={40},
  pages={970–972}
}
Objective:Very few data are available for critically ill patients with central or extrapontine myelinolysis and according to available evidence, the prognosis seems to be poor. We aimed to describe the baseline characteristics, the management, the long-term prognosis, and the prognostic factors in central or extrapontine myelinolysis. Design:Retrospective observational study considering modified Rankin Scale score >3 or death as an unfavorable outcome. Setting:Forty-six French intensive care… Expand
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References

SHOWING 1-10 OF 10 REFERENCES
Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome (central pontine and/or extrapontine myelinolysis) in 25 patients
TLDR
Higher GCS scores, better scores in functional scales in hospital, less severe hyponatraemia and absence of superadded hypokalaemia predicted favourable outcome. Expand
Outcome of central pontine and extrapontine myelinolysis (n = 44)
TLDR
It is concluded that patients with cerebral myelinolysis survive if the nonspecific secondary complications of transient illnesses such as aspiration pneumonia, ascending urinary tract infection with subsequent septicemia, deep venous thrombosis, and pulmonary embolism can be avoided. Expand
Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies
TLDR
The data show that individual patients in traditionally “poor outcome” categories can have a reasonable neurologic outcome when treated aggressively, and the most important prognostic variable in determining outcome after ICH is the level of medical support provided. Expand
Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes
  • R. Martin
  • Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • 2004
TLDR
The clinical, pathological, and aetiological features of the disease, the dilemma facing clinicians treating patients with severe hyponatraemia, and treatment opportunities are discussed. Expand
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.
TLDR
The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis and is a starting point for future evaluation of the efficiency of intensive care units. Expand
Osmotic demyelination syndrome following correction of hyponatremia: association with hypokalemia.
  • J. Lohr
  • Medicine
  • The American journal of medicine
  • 1994
TLDR
In neurologically stable patients with severe hyponatremia, it may be beneficial to correct hypokalemia prior to correction of the serum sodium, which may further reduce the incidence of ODS. Expand
Central pontine and extrapontine myelinolysis: a report of 58 cases.
TLDR
Extrapontine lesions seem to be more frequent and widespread than has been hitherto reported in the literature and one case with an extreme extension of the lesions is described in detail. Expand
The UK-TIA aspirin trial: Interim results
  • BMJ
  • 1988
Philippe Guiot, MD (Mulhouse, Site Investigator)
  • Site Investigator), Julien Maizel (Amiens University Hospital, Site Investigator)