Long-term outcome of paediatric-onset multiple sclerosis: a population-based study.

  title={Long-term outcome of paediatric-onset multiple sclerosis: a population-based study.},
  author={Katharine Elizabeth Harding and Kate Liang and Mark D Cossburn and Gillian Ingram and Claire L Hirst and Trevor P Pickersgill and Johann te Water Naud{\'e} and Mark Wardle and Y Ben-Shlomo and Neil P. Robertson},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={84 2},
BACKGROUND Age of onset of multiple sclerosis (MS) peaks in the 3rd and 4th decades and is rarely less than 18. Robust longitudinal studies in paediatric-onset MS (POMS) are limited, and a clearer understanding of outcome could optimise management strategies. METHODS Patients with disease onset <18 years were identified from a prospective population-based register. Clinical features including presenting symptoms, time to Expanded Disability Status Scale (EDSS) 4.0, 6.0 and 8.0 and onset of… CONTINUE READING
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