Long-term outcome of interferon-alpha-induced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment.

@article{Carella2001LongtermOO,
  title={Long-term outcome of interferon-alpha-induced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment.},
  author={Carlo Carella and Gherardo Mazziotti and Filomena Morisco and Giovanni Manganella and Mario Rotondi and Concetta Tuccillo and Francesca Sorvillo and Nicola Caporaso and Giovanni Amato},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 5},
  pages={
          1925-9
        }
}
Thyroid autoimmunity and dysfunction have been widely reported as side effects of interferon-alpha (IFN-alpha) treatment, but the literature lacks data regarding the long-term course of these complications, clinical observation being limited to 6-12 months off therapy. Our study is the first that has aimed to evaluate the natural history of IFN-related thyroid autoimmunity during a 6.2-yr follow-up after the IFN-alpha withdrawal as well as to investigate the potential role of the autoantibody… CONTINUE READING
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