Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.

  title={Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.},
  author={Claudio M Pacella and Giampiero Francica and F. Marta L. Di Lascio and Vincenzo Arienti and Ettore Antico and Bruno Caspani and Fabrizio Magnolfi and Angelo Salomone Megna and Stefano Pretolani and Renato Regine and Massimo Sponza and Roberto Stasi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={27 16},
PURPOSE Percutaneous laser ablation (PLA) has been proposed as an active treatment in patients with hepatocellular carcinoma (HCC). However, large multicenter studies using this technique have not been reported. PATIENTS AND METHODS We retrospectively analyzed treatment and survival parameters of 432 cirrhotic patients with nonsurgical early HCC (single nodule < or = 4 cm or three nodules < or = 3 cm each) who had received PLA in nine Italian centers. RESULTS Single tumors were seen in 344… 
Long-term effectiveness of radiofrequency ablation for solitary small hepatocellular carcinoma: a retrospective analysis of 363 patients.
  • G. Francica, Antonio Saviano, M. Pompili
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2013
Laser ablation is superior to TACE in large-sized hepatocellular carcinoma: a pilot case–control study
LA is a more effective therapeutic option than TACE in patients with solitary large HCC, especially in nodules ranging between 51 and 60 mm in diameter, with a complete response rate post-LA and post-TACE of 75% and 14.3%, respectively.
Proton beam therapy for hepatocellular carcinoma: a comparison of three treatment protocols.
Effectiveness, safety, and local progression after percutaneous laser ablation for hepatocellular carcinoma nodules up to 4 cm are not affected by tumor location.
When laser ablation is used to treat small HCC nodules, tumor location does not have a significant negative impact on the technique's primary effectiveness or safety or on its ability to achieve local control of disease.
Influence of ablative margin on local tumor progression and survival in patients with HCC ≤4 cm after laser ablation
An ablative margin ≥7.5 mm turned out to be useful in preventing local tumor progression but did not affect long-term survival in patients with HCC ≤4 cm treated with US-guided laser ablation.
Laser ablation for small hepatocellular carcinoma: State of the art and future perspectives.
A review of published data suggests that LA is equivalent to the more popular and widespread radiofrequency ablation in both local tumor control and long-term outcome in the percutaneous treatment of early HCC.
Local ablative treatments for hepatocellular carcinoma: An updated review
There is increasing evidence that combining RFA to transarterial chemoembolization may increase the therapeutic benefit in larger HCCs without increasing the major complication rate, but more robust prospective data is still needed to validate these pivotal findings.
Percutaneous Laser Ablation of Liver Metastases from Neuroendocrine Neoplasm. A Retrospective Study for Safety and Effectiveness
LA is a promising and safe technique to treat LM from NEN and a longer follow-up should provide definitive information on the long-term efficacy of this liver-directed therapy.


Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma
It is demonstrated that initial complete response to percutaneous ablation is associated with an improved survival in both Child‐Turcotte‐Pugh class A and B patients with nonsurgical HCC, and initial complete tumor necrosis should be considered a relevant therapeutic target irrespective of tumor size and liver function.
Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation.
RF ablation is an effective first-line treatment for cirrhotic patients with early-stage HCC who were excluded from surgery and who had Child class A or B cirrhosis with either a single HCC less than or equal to 5 cm in diameter or multiple (as many as three) HCCs less than and equal to 3cm in diameter each.
Complications of laser ablation for hepatocellular carcinoma: a multicenter study.
Percutaneous LA may be considered a safe treatment for small HCCs and primary effectiveness rates were 60% in all H CCs and 81% in HCCS smaller than 3 cm.
Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: a European experience
Evaluating the long-term results of percutaneous ethanol injection for the treatment of hepatocellular carcinoma (HCC) in patients with liver cirrhosis found long- term survival of cirrhotic patients with HCC treated with PEI is comparable to that reported in published series of matched patients submitted to surgical resection.
Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection.
RF ablation is superior to PEI with respect to local recurrence-free survival rates with multivariate analysis and prognostic value of treatment techniques was assessed with univariate and multivariate Cox proportional hazards regression models.
Laser thermal ablation in the treatment of small hepatocellular carcinoma: results in 74 patients.
LTA is a safe and effective treatment for small HCC and cancer-free survival rates were 99, 68, and 15% at 1, 3, and 5 years, respectively.