Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.

@article{Pacella2009LongtermOO,
  title={Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.},
  author={Claudio M Pacella and Giampiero Francica and F. Marta L. Di Lascio and Vincenzo Arienti and Ettore Antico and Bruno Caspani and Fabrizio Magnolfi and Angelo Salomone Megna and Stefano Pretolani and Renato Regine and Massimo Sponza and Roberto Stasi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 16},
  pages={
          2615-21
        }
}
PURPOSE Percutaneous laser ablation (PLA) has been proposed as an active treatment in patients with hepatocellular carcinoma (HCC). However, large multicenter studies using this technique have not been reported. PATIENTS AND METHODS We retrospectively analyzed treatment and survival parameters of 432 cirrhotic patients with nonsurgical early HCC (single nodule < or = 4 cm or three nodules < or = 3 cm each) who had received PLA in nine Italian centers. RESULTS Single tumors were seen in 344… 
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    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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TLDR
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TLDR
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TLDR
It is demonstrated that initial complete response to percutaneous ablation is associated with an improved survival in both Child‐Turcotte‐Pugh class A and B patients with nonsurgical HCC, and initial complete tumor necrosis should be considered a relevant therapeutic target irrespective of tumor size and liver function.
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TLDR
RF ablation is an effective first-line treatment for cirrhotic patients with early-stage HCC who were excluded from surgery and who had Child class A or B cirrhosis with either a single HCC less than or equal to 5 cm in diameter or multiple (as many as three) HCCs less than and equal to 3cm in diameter each.
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TLDR
Percutaneous LA may be considered a safe treatment for small HCCs and primary effectiveness rates were 60% in all H CCs and 81% in HCCS smaller than 3 cm.
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Evaluating the long-term results of percutaneous ethanol injection for the treatment of hepatocellular carcinoma (HCC) in patients with liver cirrhosis found long- term survival of cirrhotic patients with HCC treated with PEI is comparable to that reported in published series of matched patients submitted to surgical resection.
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RF ablation is superior to PEI with respect to local recurrence-free survival rates with multivariate analysis and prognostic value of treatment techniques was assessed with univariate and multivariate Cox proportional hazards regression models.
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TLDR
LTA is a safe and effective treatment for small HCC and cancer-free survival rates were 99, 68, and 15% at 1, 3, and 5 years, respectively.
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