Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.

@article{Pacella2009LongtermOO,
  title={Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis.},
  author={Claudio M Pacella and Giampiero Francica and F. Marta L. Di Lascio and Vincenzo Arienti and Ettore Antico and Bruno Caspani and Fabrizio Magnolfi and Angelo Salomone Megna and Stefano Pretolani and Renato Regine and Massimo Sponza and Roberto Stasi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 16},
  pages={
          2615-21
        }
}
PURPOSE Percutaneous laser ablation (PLA) has been proposed as an active treatment in patients with hepatocellular carcinoma (HCC). However, large multicenter studies using this technique have not been reported. PATIENTS AND METHODS We retrospectively analyzed treatment and survival parameters of 432 cirrhotic patients with nonsurgical early HCC (single nodule < or = 4 cm or three nodules < or = 3 cm each) who had received PLA in nine Italian centers. RESULTS Single tumors were seen in 344… 
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122 Citations

Long-term effectiveness of radiofrequency ablation for solitary small hepatocellular carcinoma: a retrospective analysis of 363 patients.
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  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2013
Laser ablation is superior to TACE in large-sized hepatocellular carcinoma: a pilot case–control study
TLDR
LA is a more effective therapeutic option than TACE in patients with solitary large HCC, especially in nodules ranging between 51 and 60 mm in diameter, with a complete response rate post-LA and post-TACE of 75% and 14.3%, respectively.
Increased survival in hepatocellular carcinoma with iodine-125 implantation plus radiofrequency ablation: a prospective randomized controlled trial.
Treatment results and prognostic factors in resectable hepatocellular carcinoma—Results from a local general hospital
Proton beam therapy for hepatocellular carcinoma: a comparison of three treatment protocols.
Effectiveness, safety, and local progression after percutaneous laser ablation for hepatocellular carcinoma nodules up to 4 cm are not affected by tumor location.
TLDR
When laser ablation is used to treat small HCC nodules, tumor location does not have a significant negative impact on the technique's primary effectiveness or safety or on its ability to achieve local control of disease.
Influence of ablative margin on local tumor progression and survival in patients with HCC ≤4 cm after laser ablation
TLDR
An ablative margin ≥7.5 mm turned out to be useful in preventing local tumor progression but did not affect long-term survival in patients with HCC ≤4 cm treated with US-guided laser ablation.
Laser ablation for small hepatocellular carcinoma: State of the art and future perspectives.
TLDR
A review of published data suggests that LA is equivalent to the more popular and widespread radiofrequency ablation in both local tumor control and long-term outcome in the percutaneous treatment of early HCC.
Local ablative treatments for hepatocellular carcinoma: An updated review
TLDR
There is increasing evidence that combining RFA to transarterial chemoembolization may increase the therapeutic benefit in larger HCCs without increasing the major complication rate, but more robust prospective data is still needed to validate these pivotal findings.
Percutaneous Laser Ablation of Liver Metastases from Neuroendocrine Neoplasm. A Retrospective Study for Safety and Effectiveness
TLDR
LA is a promising and safe technique to treat LM from NEN and a longer follow-up should provide definitive information on the long-term efficacy of this liver-directed therapy.
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