Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy. A randomized double-blind casein-controlled trial. The Italian Multicenter Study Group.

@article{Marchesini1990LongtermOB,
  title={Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy. A randomized double-blind casein-controlled trial. The Italian Multicenter Study Group.},
  author={Giulio Marchesini and Francesco Saverio Dioguardi and Giampaolo Bianchi and Marco Zoli and Giorgio Bellati and Luigi Roffi and Diego Martines and Roberto Andrea Abbiati},
  journal={Journal of hepatology},
  year={1990},
  volume={11 1},
  pages={92-101}
}
In a double blind randomized study, branched-chain amino acids and placebo (casein) were compared as a treatment for chronic hepatic encephalopathy in cirrhosis. After a 15-day run-in period with controlled diet (45-65 g protein), the patients were administered, in addition to their diet, branched-chain amino acids (0.24 g/kg, 30 patients) or an equinitrogenous amount of casein (34 patients). One patient on branched-chain amino acids and two on casein were lost to the study. After 3 months, the… CONTINUE READING
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