Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome.

@article{Corrales2013LongtermOA,
  title={Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome.},
  author={Andrea Corrales and P. A. Mart{\'i}nez and Susana Navarro Garc{\'i}a and Ver{\^o}nica Lopes Louzada Vidal and Eva Garc{\'i}a and Jes{\'u}s Fl{\'o}rez and Emilio Jos{\'e} S{\'a}nchez-Barcel{\'o} and Carmen Mart{\'i}nez-Cu{\'e} and N. Martinez Rueda},
  journal={Journal of pineal research},
  year={2013},
  volume={54 3},
  pages={346-58}
}
Ts65Dn mice (TS), the most commonly used model of Down syndrome (DS), exhibit phenotypic characteristics of this condition. Both TS mice and DS individuals present cognitive disturbances, age-related cholinergic degeneration, and increased brain expression of β-amyloid precursor protein (AβPP). These neurodegenerative processes may contribute to the progressive cognitive decline observed in DS. Melatonin is a pineal indoleamine that has been reported to reduce neurodegenerative processes and… CONTINUE READING
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