Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies: a novel insight into the molecular pathogenesis of ovarian epithelial carcinoma.

@article{Motohara2010LongtermOO,
  title={Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies: a novel insight into the molecular pathogenesis of ovarian epithelial carcinoma.},
  author={Takeshi Motohara and Hironori Tashiro and Yo Miyahara and Isao Sakaguchi and Hideyuki Ohtake and Hidetaka Katabuchi},
  journal={Cancer science},
  year={2010},
  volume={101 6},
  pages={1550-6}
}
A two-tier system in which ovarian epithelial carcinomas are subdivided into type I and type II tumors has been proposed on the basis of recent molecular pathogenesis findings. Type I tumors, unrelated to tumor protein p53 (TP53) mutations, show favorable prognosis in a slow step-wise process, whereas type II tumors, related to TP53 mutations, contribute to poor prognosis. Ovarian serous carcinomas with excessive psammoma bodies behave like type I tumors. However, their etiology and prognostic… CONTINUE READING
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