Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer.

@article{Guillem2005LongtermOO,
  title={Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer.},
  author={Jos{\'e} G. Guillem and David B. Chessin and Alfred M. Cohen and Jinru Shia and Madhu Mazumdar and Warren E. Enker and Philip B. Paty and Martin R Weiser and David S. Klimstra and Leonard L Saltz and Bruce Daniel Minsky and W. Douglas Wong},
  journal={Annals of surgery},
  year={2005},
  volume={241 5},
  pages={829-36; discussion 836-8}
}
OBJECTIVE Our aims were to (1) determine the long-term oncologic outcome for patients with rectal cancer treated with preoperative combined modality therapy (CMT) followed by total mesorectal excision (TME), (2) identify factors predictive of oncologic outcome, and (3) determine the oncologic significance of the extent of pathologic tumor response. SUMMARY BACKGROUND DATA Locally advanced (T3-4 and/or N1) rectal adenocarcinoma is commonly treated with preoperative CMT and TME. However, the… CONTINUE READING
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