Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa.

@article{KlinkenbergKnol2000LongtermOT,
  title={Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa.},
  author={Elly C. Klinkenberg-Knol and Frits G Nelis and John Dent and Pleun Snel and B Egan Mitchell and Paul Dehnhardt Prichard and Deborah Lloyd and N. Havu and Marie Frame and J Roman and Anders Walan},
  journal={Gastroenterology},
  year={2000},
  volume={118 4},
  pages={661-9}
}
BACKGROUND & AIMS The efficacy and safety of long-term acid suppression remains a subject for debate. We report data from patients with refractory reflux esophagitis who were undergoing maintenance therapy with >/=20 mg omeprazole daily for a mean period of 6.5 years (range, 1.4-11.2 years). METHODS Patients with severe reflux esophagitis resistant to long-term therapy with H(2)-receptor antagonists and who were not eligible for surgery were evaluated at least annually for endoscopic relapse… CONTINUE READING

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