Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling.

@article{LimaLeopoldo2014LongtermOP,
  title={Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling.},
  author={Ana Paula Lima-Leopoldo and Andr{\'e} Soares Leopoldo and Danielle Cristina Tomaz da Silva and Andr{\'e} Ferreira do Nascimento and Dijon Henrique Salom{\'e} de Campos and Renata A M Luvizotto and Adriana Fernandes de Deus and Paula Paccielli Freire and Alessandra Medeiros and K Okoshi and Ant{\^o}nio Carlos Cicogna},
  journal={Journal of applied physiology},
  year={2014},
  volume={117 6},
  pages={
          669-78
        }
}
Few studies have evaluated the relationship between the duration of obesity, cardiac function, and the proteins involved in myocardial calcium (Ca(2+)) handling. We hypothesized that long-term obesity promotes cardiac dysfunction due to a reduction of expression and/or phosphorylation of myocardial Ca(2+)-handling proteins. Thirty-day-old male Wistar rats were distributed into two groups (n = 10 each): control (C; standard diet) and obese (Ob; high-fat diet) for 30 wk. Morphological and… CONTINUE READING
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