Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril.

@article{Heitzer1998LongtermNT,
  title={Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril.},
  author={Thomas Heitzer and Hanjoerg Just and Carsten Brockhoff and Thomas Meinertz and M. Olschewski and Thomas F. M{\"u}nzel},
  journal={Journal of the American College of Cardiology},
  year={1998},
  volume={31 1},
  pages={83-8}
}
OBJECTIVES We examined whether long-term nitroglycerin (NTG) treatment leads to an increase in sensitivity to vasoconstrictors. To assess a potential role of the renin-angiotensin system in mediating this phenomenon, we treated patients concomitantly with the angiotensin-converting enzyme (ACE) inhibitor captopril. BACKGROUND The anti-ischemic efficacy of organic nitrates is rapidly blunted by the development of nitrate tolerance. The underlying mechanisms are most likely multifactorial and… CONTINUE READING
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A role for angiotensin II in nitrate tolerance: chronic AT-1 receptor blockade prevents development of tolerance and cross tolerance [abstract

  • S Kurz, T Munzel, DG. Harrison
  • Circulation
  • 1995
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