Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

Abstract

Sustained oxidative stress is a known sequel to focal cerebral ischemia. This study examined the effects of treatment with a single dose or sustained infusion of the redox-modulating MnPorphyrin Mn(III)TDE-2-ImP(5+) on outcome from middle cerebral artery occlusion (MCAO) in the rat. Normothermic rats were subjected to 90 min MCAO followed by 90 min… (More)
DOI: 10.1016/j.freeradbiomed.2009.05.039

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@article{Sheng2009LongtermNF, title={Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.}, author={Huaxin Sheng and Wei Yang and Shiro Fukuda and Hubert M Tse and Wulf Paschen and Kwame Johnson and Ines Batini{\'c}-Haberle and James D. Crapo and Robert D. Pearlstein and Jon D Piganelli and David S. Warner}, journal={Free radical biology & medicine}, year={2009}, volume={47 7}, pages={917-23} }