Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis.

@article{Keefe2006LongtermNE,
  title={Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis.},
  author={Richard S. E. Keefe and Larry J. Seidman and Bruce K. Christensen and Robert M. Hamer and Tonmoy Sharma and M. M. Sitskoorn and Stephanie L. Rock and Sandra Woolson and Mauricio Tohen and Gary D. Tollefson and Todd M Sanger and Jeffrey A. Lieberman},
  journal={Biological psychiatry},
  year={2006},
  volume={59 2},
  pages={97-105}
}
BACKGROUND Neurocognitive deficits are severe in first-episode psychosis. METHODS Patients (N = 263) with first-episode psychosis (schizophrenia, schizoaffective, or schizophreniform disorders) were randomly assigned to double-blind treatment with olanzapine (mean 11.30 mg/day) or haloperidol (mean 4.87 mg/day) for 104 weeks. A neurocognitive battery was administered at baseline (n = 246) and 12 (n = 167), 24 (n = 126), 52 (n = 89), and 104 (n = 46) weeks during treatment. Weighted principal… CONTINUE READING