Long-term modulation of Ca2+-stimulated autophosphorylation and subcellular distribution of the Ca2+/calmodulin-dependent protein kinase in the brain of Drosophila.

@article{Willmund1986LongtermMO,
  title={Long-term modulation of Ca2+-stimulated autophosphorylation and subcellular distribution of the Ca2+/calmodulin-dependent protein kinase in the brain of Drosophila.},
  author={R Willmund and H Mitschulat and Katja Susanne Annika Ilse Margret Schneider},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 24},
  pages={9789-93}
}
After prolonged visual adaptation of Drosophila, dramatic long-term changes of in vitro phosphorylation of a 50-kDa brain protein that is identical to the Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.37) can be measured in isolated heads. By selective receptor cell desensitization in blue light, subcellular distribution of the 50-kDa kinase in fly brain is modified, and Ca2+-stimulated in vitro phosphorylation is increased. Concomitantly the 50-kDa kinase is translocated by in vitro… CONTINUE READING