Long-term mineralocorticoid-induced changes in rat neuron properties plus interaction of aldosterone and ANG II.

@article{Thornton1994LongtermMC,
  title={Long-term mineralocorticoid-induced changes in rat neuron properties plus interaction of aldosterone and ANG II.},
  author={Simon Nigel Thornton and S. Nicola{\"i}dis},
  journal={The American journal of physiology},
  year={1994},
  volume={266 2 Pt 2},
  pages={R564-71}
}
The central site of action and the neuronal mechanism of the robust sodium appetite initiated in rats by the synergistic action of a peripheral priming with mineralocorticoid [deoxycorticosterone acetate (DOCA)] and subsequent central angiotensin II (ANG II) were investigated using iontophoretic and electrophysiological techniques in urethan-anesthetized, DOCA-pretreated (0.5 mg/day sc for 3 days) or nonpretreated male Wistar rats. A significantly greater number of spontaneously active neurons… CONTINUE READING