Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

@inproceedings{Lentferink2018LongtermMT,
  title={Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study},
  author={Y E Lentferink and Marloes P van der Aa and E. G. A. H. van Mill and Catherijne A J Knibbe and Marja M J van der Vorst},
  booktitle={Nutrition & Diabetes},
  year={2018}
}
Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month open label extension study following an 18 months randomized placebo-controlled trial (RCT) on the efficacy, safety, and tolerability of metformin in adolescents with obesity and insulin resistance was performed. After completion of the RCT, metformin was offered to all participants with a… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

a randomized controlled trial

Pastor-Villaescusa, B. et al. Metformin for obesity in prepubertal, pubertal children
  • Pediatrics 140. https://doi.org/10.1542/ peds.2016-4285
  • 2017

a systematic review and call for consensus

M. P. van der Aa, C. A. Knibbe, A. Boer, van der Vorst, M. M. Definition of insulin resistance affects preval patients
  • J. Pediatr. Endocrinol. Metab. 30, 123–131
  • 2017

from epidemiology, etiology, and comorbidities to clinical assessment and treatment

S. Kumar, Kelly, A. S. Review of childhood obesity
  • Mayo Clinic Proc. 92, 251–265
  • 2017

1990–2015

World Health Organisation. Global, regional trends bij UN regions, 1990–2025 overweight
  • http://apps.who.int/gho/data/view.main. NUTUNOVERWEIGHTv?lang=en. Accessed February 2017
  • 2016

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