Long-term low-dose IL-2 enhances immune function in common variable immunodeficiency.

  title={Long-term low-dose IL-2 enhances immune function in common variable immunodeficiency.},
  author={Charlotte Cunningham-Rundles and Carol A. Bodian and Hans D. Ochs and Simona Martin and M Reiter-Wong and Zhihong Zhuo},
  journal={Clinical immunology},
  volume={100 2},
Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by hypogammaglobulinemia and lack of antibody production. Numerous T cell defects have been described, including reduced gene expression and production of IL-2. Since some of the T cell defects could be explained by lack of IL-2, we have been investigating the effects of in vivo IL-2 treatment. Here, a long-acting form of IL-2, PEG-IL-2, was given for 12-18 months to 15 randomly chosen CVID subjects, in… CONTINUE READING
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