Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice.

@article{Ellenbroek2014LongtermKD,
  title={Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice.},
  author={Johanne H Ellenbroek and Laura van Dijck and Hendrica A M T{\"o}ns and Ton J. Rabelink and Françoise Carlotti and Bart E P B Ballieux and Eelco J P de Koning},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 5},
  pages={
          E552-8
        }
}
High-fat, low-carbohydrate ketogenic diets (KD) are used for weight loss and for treatment of refractory epilepsy. Recently, short-time studies in rodents have shown that, besides their beneficial effect on body weight, KD lead to glucose intolerance and insulin resistance. However, the long-term effects on pancreatic endocrine cells are unknown. In this study we investigate the effects of long-term KD on glucose tolerance and β- and α-cell mass in mice. Despite an initial weight loss, KD did… CONTINUE READING
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Glucagon - like peptide - 1 receptor agonist treatment reduces beta cell mass in normogly - caemic mice

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