Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice.

@article{Tsuduki2011LongtermIO,
  title={Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice.},
  author={Tsuyoshi Tsuduki and Taro Honma and Kiyotaka Nakagawa and Ikuo Ikeda and Teruo Miyazawa},
  journal={Nutrition},
  year={2011},
  volume={27 3},
  pages={
          334-7
        }
}

• Tsuyoshi Tsuduki, Taro Honma, +2 authors Teruo Miyazawa
• Published in Nutrition 2011
• DOI:10.1016/j.nut.2010.05.017

OBJECTIVE The effects of fish oil including ω-3 polyunsaturated fatty acids on aging and lifespan are not well understood. In this study, the influence of long-term ingestion of fish oil on lifespan was examined in senescence-accelerated (SAMP8) mice. METHODS We investigated the effects of dietary fish oil on lifespan and on lipid composition and oxidative stress in plasma and liver in SAMP8 mice. Male mice were fed a fish oil diet (5% fish oil and 5% safflower oil) or a safflower oil diet… CONTINUE READING

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