Long-term inhibition of myocardial infarction by postconditioning during reperfusion

@article{Mykytenko2006LongtermIO,
  title={Long-term inhibition of myocardial infarction by postconditioning during reperfusion},
  author={James Mykytenko and Faraz Kerendi and James G. Reeves and Hajime Kin and Amanda J. Zatta and Rong Jiang and Robert A. Guyton and Jakob Vinten-Johansen and PhD Z.-Q. Zhao},
  journal={Basic Research in Cardiology},
  year={2006},
  volume={102},
  pages={90-100}
}
Cardioprotection with postconditioning has been well demonstrated after a short period of reperfusion. This study tested the hypothesis that postconditioning reduces infarct size, vascular dysfunction, and neutrophil accumulation after a long-term reperfusion. Canines undergoing 60 min left anterior descending artery (LAD) occlusion were divided into two control groups of either 3 h or 24 h of full reperfusion and two postconditioning groups with three 30 s cycles of reperfusion and re… CONTINUE READING