Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA

@article{Chen2007LongtermIO,
  title={Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA},
  author={C Chen and T-M Ko and Haiqiu Ma and H Wu and Xiao Xiao and Jisu Li and C-M Chang and P Wu and Cheng-Hsu Chen and J-M Han and C Yu and K S Jeng and C Hu and M-H Tao},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={11-19}
}
RNA interference (RNAi) was reported to block hepatitis B virus (HBV) gene expression and replication in vitro and in vivo. However, it remains a technical challenge for RNAi-based therapy to achieve long-term and complete inhibition effects in chronic HBV infection, which presumably requires more extensive and uniform transduction of the whole infected hepatocytes. To increase the in vivo transfection efficiency in liver, we used a double-stranded adeno-associated virus 8-pseudotyped vector… CONTINUE READING

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Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs.

Molecular therapy : the journal of the American Society of Gene Therapy • 2006

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