Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.

  title={Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.},
  author={Michele D'Amico and Clara Di Filippo and Raffaele Marfella and Angela Maria Abbatecola and Franca Ferraraccio and Francesco Rossi and Guiseppe Paolisso},
  journal={Experimental gerontology},
  volume={45 3},
We tested here the impact of a long-term inhibition of dipeptidyl peptidase-4 (DPP-4) with sitagliptin on the deposition of amyloid-beta within the brain and deficits in memory-related behavioral paradigms in a model of Alzheimer's disease (AD): double transgenic mice B6*Cg-Tg(APPswe,PSEN1dE9)85Dbo/J. Mice began to receive sitagliptin at 7 months of age. Three different dose of sitagliptin (5, 10 and 20 mg/kg), were administered daily for 12 weeks by gastric gavage. The treatments counteracted… CONTINUE READING

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