Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

@article{Hattori2004LongtermIO,
  title={Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.},
  author={Tsuyoshi Hattori and Hiroaki Shimokawa and Midoriko Higashi and Junko Hiroki and Yasushi Mukai and Hiroyuki Tsutsui and Kozo Kaibuchi and Akira Takeshita},
  journal={Circulation},
  year={2004},
  volume={109 18},
  pages={2234-9}
}
BACKGROUND Rho-kinase has been implicated as an important regulator of inflammatory responses mediated by cytokines and chemokines. Because proinflammatory cytokines play a critical role in left ventricular (LV) remodeling after myocardial infarction (MI), we examined whether long-term blockade of Rho-kinase suppresses LV remodeling in a mouse model of MI in vivo. METHODS AND RESULTS Mice underwent ligation of the left coronary artery and were treated with a Rho-kinase inhibitor, fasudil (100… CONTINUE READING

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