Long-term in vivo transduction of neurons throughout the rat CNS using novel helper-dependent CAV-2 vectors.

Numerous genetic and environmental causes, variable pathophysiologies, and the blood-brain barrier create a formidable challenge for the study and treatment of neurodegenerative diseases affecting the central nervous system. Although there are many intracellular strategies to address neurodegeneration, for example, which transgene to use, one fundamental… CONTINUE READING