Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum.

@article{Nishiyama2014LongtermIV,
  title={Long-term in vivo time-lapse imaging of synapse development and plasticity in the cerebellum.},
  author={Naoko Nishiyama and Jeremy Colonna and Elise Ting-Hsin Shen and Jennifer Carrillo and Hiroshi Nishiyama},
  journal={Journal of neurophysiology},
  year={2014},
  volume={111 1},
  pages={208-16}
}
Synapses are continuously formed and eliminated throughout life in the mammalian brain, and emerging evidence suggests that this structural plasticity underlies experience-dependent changes of brain functions such as learning and long-term memory formation. However, it is generally difficult to understand how the rewiring of synaptic circuitry observed in vivo eventually relates to changes in animal's behavior. This is because afferent/efferent connections and local synaptic circuitries are… CONTINUE READING
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