Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.

@article{Walker2000LongtermIV,
  title={Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.},
  author={Robert E. Walker and Ch. Bechtel and Ven Natarajan and Michael W. Baseler and Kristen M. Hege and Julia A. Metcalf and Richard S. Stevens and Allison Hazen and R. Michael Blaese and Clara C. Chen and Susan F. Leitman and Jolie Palensky and Janet Wittes and Richard T. Davey and Judith Falloon and Michael A. Polis and Joseph A Kovacs and David F Broad and Bruce L Levine and Margo R. Roberts and Henry Masur and H. Clifford Lane},
  journal={Blood},
  year={2000},
  volume={96 2},
  pages={467-74}
}
To study human immunodeficiency virus (HIV)-specific cellular immunity in vivo, we transferred syngeneic lymphocytes after ex vivo expansion and transduction with a chimeric receptor gene (CD4/CD3-zeta) between identical twins discordant for HIV infection. Single and multiple infusions of 10(10) genetically modified CD8(+) T cells resulted in peak fractions in the circulation of approximately 10(4) to 10(5) modified cells/10(6) mononuclear cells at 24 to 48 hours, followed by 2- to 3-log… CONTINUE READING
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