Long-term in vivo response to citric acid-based nanocomposites for orthopaedic tissue engineering.

  title={Long-term in vivo response to citric acid-based nanocomposites for orthopaedic tissue engineering.},
  author={Eun Ji Chung and Pradeep Kodali and William Bradlyn Laskin and Jason Lee Koh and Guillermo A Ameer},
  journal={Journal of materials science. Materials in medicine},
  volume={22 9},
The disadvantages of current bone grafts have triggered the development of a variety of natural and synthetic bone substitutes. Previously, we have described the fabrication, characterization, and short-term tissue response of poly(1,8-octanediol-co-citrate) (POC) with 60 weight % hydroxyapatite nanocrystals (POC-HA) at 6 weeks. In order to better understand the clinical potential, longer term effects, and the biodegradation, biocompatibility, and bone regenerative properties of these novel… CONTINUE READING


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