Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study.

@article{Oberbauer2003LongtermII,
  title={Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study.},
  author={Rainer Oberbauer and Henri A Kreis and Robert Wood Johnson and A. O. Mota and Kerstin Claesson and Juan Carlos Ruiz and Henryk Wilczek and N. S. D. Jamieson and Ant{\'o}nio Castro ‐ Henriques and Leszek Paczek and Jeremy Chapman and J. H. T. Burke},
  journal={Transplantation},
  year={2003},
  volume={76 2},
  pages={364-70}
}
INTRODUCTION The purpose of this study was to evaluate early cyclosporine (CsA) withdrawal from a sirolimus (SRL)-CsA-steroid (ST) regimen. METHODS Within 48 hr after transplantation, 525 primary (90%) or secondary (10%) renal allograft recipients with cadaveric (89%) or living (11%) donors received 2 mg of SRL (troughs >5 ng/mL; immunoassay), CsA, and ST. Those eligible (430) were randomly assigned (1:1) at 3 months +/- 2 weeks to remain on triple-drug therapy (SRL-CsA-ST group) or to have… CONTINUE READING
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