Long-term impaired neutrophil migration in mice overexpressing human interleukin-8.

@article{Simonet1994LongtermIN,
  title={Long-term impaired neutrophil migration in mice overexpressing human interleukin-8.},
  author={William S Simonet and Thomas M. Hughes and Hung Q. Nguyen and Lisa D. Trebasky and Dimitry M. Danilenko and Eugene S. Medlock},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 3},
  pages={1310-9}
}
The proinflammatory chemokine interleukin-8 (IL-8/NAP-1) has been implicated in recruiting neutrophils to sites of acute and chronic tissue inflammation. In transgenic mice, elevated serum IL-8 levels ranging from 1 to 118 ng/ml were correlated with proportional increases in circulating neutrophils and proportional decreases in L-selectin expression on the surface of blood neutrophils. No change in the expression of the beta 2-integrins Mac-1 and LFA-1 was apparent on peripheral blood… CONTINUE READING