Long-term immunologic effects of thymectomy in patients with myasthenia gravis.

  title={Long-term immunologic effects of thymectomy in patients with myasthenia gravis.},
  author={Roberto Gerli and Roberto Paganelli and Andrea Cossarizza and Christina C Muscat and Giovanni Piccolo and Dorina Barbieri and Sabrina Mariotti and Daniel Monti and Onelia Bistoni and Elda Raiola and Franco Maria Venanzi and Alberto Bertotto and Claudio Franceschi},
  journal={The Journal of allergy and clinical immunology},
  volume={103 5 Pt 1},
BACKGROUND Thymectomy (Tx) is a common therapeutic option to treat myasthenia gravis (MG), but its effects on the immune system are still obscure in humans. OBJECTIVE We sought to evaluate long-term immunologic effects of therapeutic Tx in patients with MG. METHODS T- and B-cell subsets and T-cell repertoire were analyzed in 35 patients with MG, 16 with previous Tx (at least 8 years before), 6 with recent (<1 year) Tx, and 13 without Tx, as well as in 32 healthy subjects used as normal… CONTINUE READING
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