Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states.

@article{Dash2009LongtermHO,
  title={Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states.},
  author={Michael B Dash and Christopher L. Douglas and Vladyslav V Vyazovskiy and Chiara Cirelli and Giulio Tononi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 3},
  pages={620-9}
}
Neuronal firing patterns, neuromodulators, and cerebral metabolism change across sleep-waking states, and the synaptic release of glutamate is critically involved in these processes. Extrasynaptic glutamate can also affect neural function and may be neurotoxic, but whether and how extracellular glutamate is regulated across sleep-waking states is unclear. To assess the effect of behavioral state on extracellular glutamate at high temporal resolution, we recorded glutamate concentration in… CONTINUE READING

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