Long-term hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman primates.

@article{Oura2012LongtermHA,
  title={Long-term hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman primates.},
  author={Tetsu Oura and Kenichiro Yamashita and Tomomi Suzuki and Daisuke Fukumori and Masaaki Watanabe and Gentaro Hirokata and Kenji Wakayama and Masaru Taniguchi and Tsuyoshi Shimamura and Tetsuya Miura and Kazumichi Okimura and Katsutoshi Maeta and Hironori Haga and Koji Kubota and Akira Shimizu and Fumihiko Sakai and Hiroyuki Furukawa and Satoru Todo},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 7},
  pages={1740-54}
}
Blockade of the CD40-CD154 costimulatory signal is an attractive strategy for immunosuppression and tolerance induction in organ transplantation. Treatment with anti-CD154 monoclonal antibodies (mAbs) results in potent immunosuppression in nonhuman primates (NHPs). Despite plans for future clinical use, further development of these treatments was halted by complications. As an alternative approach, we have been focusing on the inhibition of the counter receptor, CD40 and have shown that a novel… CONTINUE READING
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