Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny.

@article{Ara2003LongtermHS,
  title={Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny.},
  author={Toshiaki Ara and Koji Tokoyoda and Tatsuki Sugiyama and Takeshi Egawa and Kenji Kawabata and Takashi Nagasawa},
  journal={Immunity},
  year={2003},
  volume={19 2},
  pages={257-67}
}
The physiological role of SDF-1 on hematopoietic stem cells (HSCs) remains elusive. We show that colonization of bone marrow by HSCs in addition to myeloid cells is severely impaired in SDF-1(-/-) embryos by a long-term repopulation assay. Colonization of spleen by HSCs was also affected, but to a lesser extent. Enforced expression of SDF-1 under the control of vascular-specific Tie-2 regulatory sequences could completely rescue the reduction of HSCs but not myeloid cells in SDF-1(-/-) bone… CONTINUE READING