Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model

@article{Shen2006LongtermGR,
  title={Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model},
  author={W. Shen and C. M. Lai and Christine E. Graham and Nicolette Binz and Yvonne K.Y. Lai and John Eade and Diego Guidolin and Domenico Ribatti and Sarah Dunlop and Piroska Elizabeth Rakoczy},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={1690-1701}
}
Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of diabetic retinopathy. We investigated whether transgenic mice with moderate VEGF expression in photoreceptors (trVEGF029) developed changes similar to diabetic retinopathy and whether retinopathy progressed with time. Human VEGF165 (hVEGF165) expression was analysed using ELISA and quantitative RT-PCR; serum glucose levels were also measured. Fundus fluorescein angiography (FA) was used to screen the degree of… CONTINUE READING
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