Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

@article{Joss2008LongtermFS,
  title={Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.},
  author={Rozenn Joss{\'e} and Caroline Aninat and Denise Glaise and Julie Dumont and Val{\'e}rie Fessard and Fabrice Morel and J Poul and Christiane Guguen-Guillouzo and Andr{\'e} Guillouzo},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 6},
  pages={1111-8}
}
The human hepatoma HepaRG cells are able to differentiate in vitro into hepatocyte-like cells and to express various liver-specific functions, including the major cytochromes P450. This study was aimed to determine whether differentiated HepaRG cells retained their specific functional capacities for a long time period at confluence. We show that expression of transcripts encoding CYP1A2, 2B6, 3A4, and 2E1, several phase II and antioxidant enzymes, membrane transporters, including organic cation… CONTINUE READING

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