Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferon

@article{Anlar1997LongtermFO,
  title={Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferon},
  author={Banu Anlar and Kalbiye Yalaz and Ferhunde Oktem and Gulşen Kose},
  journal={Neurology},
  year={1997},
  volume={48},
  pages={526 - 528}
}
Article abstract-We treated 22 patients with subacute sclerosing panencephalitis (SSPE) with intraventricular alpha-interferon (alpha-IFN) and oral inosiplex between 1986 and 1991. The follow-up for 56 to 108 months demonstrates a higher survival rate in these patients compared with those who did not receive alpha-IFN. However, eight of 11 patients whose condition improved after alpha-IFN treatment and five of five patients whose condition stabilized after alpha-IFN experienced neurologic… Expand
Long-term follow-up of a patient with subacute sclerosing panencephalitis successfully treated with intrathecal interferon alpha
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IFN-alpha-induced remission appears most likely to be temporary, even when an SSPE patient shows an excellent initial response, and more effective therapy is needed to improve long-term outcome for SSPe patients. Expand
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It is suggested that isoprinosine alone or in combination with intraventricular interferon did not change the prognosis in long-term follow-up periods. Expand
A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years
TLDR
A case report of a patient with SSPE treated with long-term intraventricular IFN-α therapy, which facilitated clinical improvement and neurological stabilization without causing serious adverse effects is presented. Expand
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TLDR
It is suggested that β-interferon might be efficient in some patients with subacute sclerosing panencephalitis and justify its trial in larger studies with longer follow-up. Expand
Retrospective evaluation of interferon-beta treatment in subacute sclerosing panencephalitis.
TLDR
The results obtained suggest that IFN-beta administered subcutaneously times per week combined with inosiplex may be an effective treatment option in SSPE. Expand
Combined treatment with interferon-alpha and ribavirin for subacute sclerosing panencephalitis.
TLDR
Treatment with intrathecal high-dose interferon-alpha and IV ribavirin is effective in the treatment of subacute sclerosing panencephalitis, suggest results suggest. Expand
Interferon alpha in subacute sclerosing panencephalitis: Case report and review of the literature
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A patient successfully treated with intraventricular INFα is reported on, a rare, rapidly progressive neurodegenerative disease caused by the measles virus that affects children and adolescents from less privileged socio-economic backgrounds in South Africa. Expand
Interferon alpha in subacute sclerosing panencephalitis : Case report and review of the literature
Subacute Sclerosing Panencephalitis (SSPE) is a rare, rapidly progressive neurodegenerative disease caused by the measles virus. Spontaneous remission and survival longer than 4 years is rare. TheExpand
Substantial spontaneous long-term remission in subacute sclerosing panencephalitis (SSPE)
TLDR
The age at onset of SSPE of > or = 12 years, disappearance of periodic complexes and a tendency for normalization of the background activity in the EEG, and a progressive increase in the measles antibody titer in the CSF appears to predict a favourable outcome of S SPE. Expand
Combined Interferon‐α and Inosiplex Treatment of Subacute Sclerosing Panencephalitis: A Case Report
  • Chy‐Yuan Han, Hsiu‐Fen Lin, Pang‐Ying Shin, Ching‐Kuan Liu, Chiang‐Shin Liu
  • Medicine
  • The Kaohsiung journal of medical sciences
  • 2003
TLDR
Oral inosiplex and intraventricular IFN‐! appear to be safe and effective in treatment of subacute sclerosing panencephalitis and early identification and aggressive treatment of SSPE is important. Expand
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