Long-term follow-up of patients with follicular lymphoma receiving single-agent rituximab at two different schedules in trial SAKK 35/98.

@article{Martinelli2010LongtermFO,
  title={Long-term follow-up of patients with follicular lymphoma receiving single-agent rituximab at two different schedules in trial SAKK 35/98.},
  author={Giovanni Martinelli and S. F. Hsu Schmitz and Urs Utiger and T. Cerny and Urs Hess and Simona Bassi and E. Okkinga and Roger Stupp and Rolf Stahel and Marc Heizmann and Daniel A. Vorobiof and Andreas Lohri and Pierre-Yves Dietrich and Emanuele Zucca and Michele Ghielmini},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 29},
  pages={
          4480-4
        }
}
PURPOSE We report the long-term results of a randomized clinical trial comparing induction therapy with once per week for 4 weeks single-agent rituximab alone versus induction followed by 4 cycles of maintenance therapy every 2 months in patients with follicular lymphoma. PATIENTS AND METHODS Patients (prior chemotherapy 138; chemotherapy-naive 64) received single-agent rituximab and if nonprogressive, were randomly assigned to no further treatment (observation) or four additional doses of… 

Rituximab Maintenance for a Maximum of 5 Years After Single-Agent Rituximab Induction in Follicular Lymphoma: Results of the Randomized Controlled Phase III Trial SAKK 35/03.

TLDR
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...

References

SHOWING 1-10 OF 24 REFERENCES

Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule.

TLDR
In patients with FL, the administration of 4 additional doses of rituximab at 8-week intervals significantly improves the EFS andCirculating normal B lymphocytes and immunoglobulin M plasma levels decreased for a significantly longer time after prolonged treatment, but the incidence of adverse events was not increased.

Rituximab as first-line and maintenance therapy for patients with indolent non-hodgkin's lymphoma.

TLDR
Rituximab is highly active and extremely well tolerated as first-line single-agent therapy for indolent NHL and produces high overall and complete response rates and a longer progression-free survival than has been reported with a standard 4-week treatment.

Long-term molecular remissions in patients with indolent lymphoma treated with rituximab as a single agent or in combination with interferon alpha-2a: A randomized phase II study from the Nordic Lymphoma Group

TLDR
Extended rituximab is effective and well tolerated and combination with IFN seems to improve both the quality and duration of the responses, providing the opportunity to achieve long-term molecular CRs and prolonged failure-free survival without chemotherapy.

Phase II trial of individualized rituximab dosing for patients with CD20-positive lymphoproliferative disorders.

TLDR
Individualized PK dosing for rituximab produced efficacy comparable to other published maintenance strategies, and PK data from this trial suggest that a rational maintenance strategy in patients with LGNHL would be a single dose of 375 mg/m(2) of ritUXimab every 3 to 4 months.

Maximizing therapeutic benefit of rituximab: maintenance therapy versus re-treatment at progression in patients with indolent non-Hodgkin's lymphoma--a randomized phase II trial of the Minnie Pearl Cancer Research Network.

TLDR
In patients who have objective response or stable disease with single-agent rituximab therapy, duration of ritUXimab benefit is substantially prolonged with either scheduled maintenance treatment or ritukimab re-treatment at the time of progression.

Patterns of survival in patients with recurrent follicular lymphoma: a 20-year study from a single center.

TLDR
Age and previous and continuing responsiveness of follicular lymphoma to therapy are the principal determinants of survival following recurrence, with improvement in survival with new treatments most readily in older patients, while more intensive approaches should be tested in younger patients in whom remission is achieved with difficulty.

High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years.

TLDR
The occurrence of a PFS plateau suggests that a subgroup of patients might have their FL cured by ASCT, however, the increased rate of secondary malignancies may discourage the use of purged ASCT in combination with TBI as first-line treatment for FL.

Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d'Etude des Lymphomes de l'Adulte (GELA).

TLDR
After long-term follow-up, the study showed that there was no statistically significant benefit in favor of first-line high-dose therapy in patients with follicular lymphoma and high- dose therapy should be reserved for relapsing patients.

Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) regimen in patients with stage IV indolent lymphoma.

TLDR
Both induction regimens followed by 1 year of interferon maintenance therapy were associated with high rates of response and survival and ATT was associated with substantially longer FFS, but it was more toxic than FND.