Long-term follow-up of 241 patients with monoclonal gammopathy of undetermined significance: the original Mayo Clinic series 25 years later.

@article{Kyle2004LongtermFO,
  title={Long-term follow-up of 241 patients with monoclonal gammopathy of undetermined significance: the original Mayo Clinic series 25 years later.},
  author={Robert A Kyle and Terry M. Therneau and S Vincent Rajkumar and Dirk Russell Larson and Matthew F. Plevak and Lee Joseph Melton},
  journal={Mayo Clinic proceedings},
  year={2004},
  volume={79 7},
  pages={859-66}
}
OBJECTIVE To determine the long-term outcome of patients with monoclonal gammopathy of undetermined significance (MGUS). PATIENTS AND METHODS We reviewed the medical records of 241 patients with MGUS who were examined at the Mayo Clinic in Rochester, Minn, between January 1, 1956, and December 31, 1970. RESULTS Follow-up was 3579 person-years (median, 13.7 years; range, 0-39 years). Only 14 patients (6%) were alive and had no substantial increase of M protein at last follow-up; 138 patients… CONTINUE READING

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