Long-term folate deficiency alters folate content and distribution differentially in rat tissues.

@article{VarelaMoreiras1992LongtermFD,
  title={Long-term folate deficiency alters folate content and distribution differentially in rat tissues.},
  author={Gregorio Varela-Moreiras and Jacob S Selhub},
  journal={The Journal of nutrition},
  year={1992},
  volume={122 4},
  pages={
          986-91
        }
}
We fed rats a defined amino acid, folate-free diet that did not contain sulfathiazole for 25 wk and examined the effects upon the content and distribution of folates in various tissues, based on the glutamic acid chain length and pteridine ring distribution. Compared with controls, rats fed the folate-deficient diet had lower folate concentrations in liver (11.10 +/- 1.04 vs. 27.11 +/- 2.72 nmol/g, P less than 0.001), kidney (4.79 +/- 0.65 vs. 11.69 +/- 1.40 nmol/g, P less than 0.01) and spleen… CONTINUE READING

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